Acetic Acid → 1-(2-Propynyl)cyclohexan-1-ol
반응식
Cl[C:2](=[CH2:11])[CH2:3][C:4]1([OH:10])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[OH-].[K+].C(O)(=O)C>CN(C)C=O>[CH2:3]([C:4]1([OH:10])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)[C:2]#[CH:11]참가 물질
5
실험 절차
10.00 Grams of the 1-(2'-chloroallyl)-1-cyclohexanol obtained above were dissolved in 94 g of N,N-dimethylformamide, and 9.65 g of potassium hydroxide in a flake form were added. The mixture was stirred at room temperature for 6 hours, and neutralized with a 20% acetic acid aqueous solution. The resultant mixture was subjected to extraction with toluene. The toluene phase was washed with water and dried over magnesium sulfate. The desiccant was filtered off and the toluene was distilled off under reduced pressure to give 7.68 g of 1-propargyl-1-cyclohexanol; m.p.=53°-54° C., FI-MS m/e 138(M+) (Propargyl compound/allene compound=100.0/0.0),
후처리
- extractionThe resultant mixture was subjected to extraction with toluene
- washThe toluene phase was washed with water
- dry with materialdried over magnesium sulfate
- filtrationThe desiccant was filtered off
- distillationthe toluene was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-f374e7e5cef14f7889a6e8368c8174ec
- 출처 데이터셋
- uspto-grants-1996_06
- 특허 번호
- US05523495
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