Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (Z)-3-(3-nitro-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-prop-2-ene-nitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3,4,5-Trimethoxyphenylacetonitrile | HCID 25887 | — |
| 반응물 | 4-Methoxy-3-nitrobenzaldehyde | HCID 700608 | — |
| 촉매 | N-Methyloctan-1-amine--hydrogen chloride (1/1) | HCID 22561414 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (Z)-3-(3-nitro-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-prop-2-ene-nitrile | HCID 10619131 | 72.4% |
반응 단계
3.0 g of 3-nitro-4-methoxybenzaldehyde, 3.4 g of 3,4,5-trimethoxyphenylacetonitrile, 800 mg of sodium hydroxide and 100 mg of octylmethylammonium chloride were dissolved in 15 ml of water and 15 ml of dichloromethane and reacted for 4 hours at room temperature. Ice water was added to the reaction liquid, which was then extracted three times each with dichloromethane. The extract was dried with anhydrous sodium sulfate and concentrated. The concentrated liquid was purified by crystallization (ethyl acetate) to obtain 4.4 g of the intended compound. The yield was 72%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05525632 |
| 출처 데이터셋 | uspto-grants-1996_06 |
| ORD ID | ord-1fc0a5e64cea4a7692a615b3c55a2b09 |
| 출처 메모 | uspto-grants-1996_06 |