Valproic Acid → 2-Propylvaleryl chloride

HRID 260201

반응식

HRID 260201 반응식
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]

참가 물질

4

반응물 2

HCID 3121Valproic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 762402-Propylvaleryl chloride

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
50 °C

실험 절차

To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.

후처리

  1. customto come to room temperature
  2. customremoved under reduced pressure
  3. customThe resultant product was used in subsequent reactions without further purification

출처 및 근거

ORD 기록
ord-7062ea72074043e7bf4ec57d183adc6d
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05525727

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