Valproic Acid → 2-Propylvaleryl chloride
반응식
[C:1]([OH:10])(=O)[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5].S(Cl)([Cl:13])=O>C1C=CC=CC=1>[C:1]([Cl:13])(=[O:10])[CH:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][CH3:5]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To 4.32 g (30 mmol) of valproic acid in an ice bath, thionyl chloride (3.60 g, 30 mmol) was slowly added, with stirring. The neat mixture was allowed to come to room temperature and then heated in a water bath at 50° C. for 30 minutes. 50 M1 portions of dry benzene were twice added and removed under reduced pressure. The resultant product was used in subsequent reactions without further purification.
후처리
- customto come to room temperature
- customremoved under reduced pressure
- customThe resultant product was used in subsequent reactions without further purification
출처 및 근거
- ORD 기록
- ord-7062ea72074043e7bf4ec57d183adc6d
- 출처 데이터셋
- uspto-grants-1996_06
- 특허 번호
- US05525727
반응 노트
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