Boc-Gly-Gly-Ala-Pro-OBzl → Boc-Gly-Gly-Ala-Pro-OH

HRID 260250노트

반응식

HRID 260250 반응식
[NH:1]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([O:18]CC1C=CC=CC=1)=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]>C(O)(=O)C.[Pd]>[NH:1]([C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:12]([N:14]1[CH2:28][CH2:27][CH2:26][C@H:15]1[C:16]([OH:18])=[O:17])=[O:13])[CH3:11])=[O:8])=[O:4]

참가 물질

4

반응물 1

HCID 131719402Boc-Gly-Gly-Ala-Pro-OBzl

생성물 1

HCID 53321812Boc-Gly-Gly-Ala-Pro-OH

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

Boc-Gly-Gly-Ala-Pro-OBzl (30.0 g, 0.061 mole) was dissolved in glacial acetic acid (300 mL) and 3.0 g of 10% Palladium on activated charcoal was added. This mixture was hydrogenated at 40 psi for 6 h. The reaction mixture was filtered through celite and the solvent was removed in vacuum. The resulting residue was triturated with ether, faltered, washed with ether, and dried to obtain Boc-Gly-Gly-Ala-Pro-OH.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent was removed in vacuum
  3. customThe resulting residue was triturated with ether
  4. washwashed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-ba75f07f17344df7bdaa8bafc0bdb6dc
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527610

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