Toluene → Benzene, (2-chloroethoxy)-

HRID 260341

반응식

HRID 260341 반응식
[O:1]([CH2:8][CH2:9]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC=CC=1.S(Cl)([Cl:20])=O>N1C=CC=CC=1>[Cl:20][CH2:9][CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 31236Phenoxyethanol

생성물 1

HCID 12156Benzene, (2-chloroethoxy)-수율 83%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a flask was added 41.5 grams (g.) (0.3 mole) of 2-phenoxyethanol, 50 ml of toluene and 3.93 g. of pyridine, then 39.3 g. (0.33 mole) of thionyl chloride dropwise while stirring at room temperature. The exothermic reaction was heated at 50°-60° C. for two hours. After cooling to room temperature, the resulting salt was filtered and washed with methylene chloride. The filtrate was washed several times with aqueous sodium bicarbonate, dried using sodium sulfate, and then concentrated to obtain 39 g. of the 1-chloro-2-phenoxyethane as a yellow oil (83% yield).

후처리

  1. customThe exothermic reaction
  2. temperaturewas heated at 50°-60° C. for two hours
  3. filtrationthe resulting salt was filtered
  4. washwashed with methylene chloride
  5. washThe filtrate was washed several times with aqueous sodium bicarbonate
  6. customdried
  7. concentrationconcentrated
  8. customto obtain 39 g

출처 및 근거

ORD 기록
ord-a5f09de4d0fd4c8084623f9223aa0406
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527816

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