참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Flurbiprofen | HCID 3394 | — |
| 생성물 | Ibuprofen, (+-)- | HCID 3672 | — |
반응 단계
Three grams of flurbiprofen and 30 g of poloxamer 237 were heated at 110° C. for 10 minutes to obtain a liquified mixture and cooled to 60° C. Into this mixture, 5 g of polyethylene glycol 300, 10 g of ethanol and 52 g of pH 4 buffer solution were added at 60° C. to obtain an ibuprofen gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05527832 |
|---|
| 출처 데이터셋 | uspto-grants-1996_06 |
|---|
| ORD ID | ord-b0ad4fad120e4b30b6d002e81134c3db |
|---|
| 출처 메모 | uspto-grants-1996_06 |
|---|
