Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 7-Bromo-4-(thiazol-4-yl)coumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Methanethioamide | HCID 3005587 | — |
| 반응물 | 7-bromo-4-(bromoacetyl)-2H-chromen-2-one | HCID 23370239 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Bromo-4-(thiazol-4-yl)coumarin | HCID 19426943 | — |
반응 단계
Freshly prepared thioformamide (Helv. Chim. Acta, 31, 2065, 1948) (160 mg) was added to a solution of (α-bromoketone from Step 2 (200 mg) in THF (5 mL) and the reaction mixture was stirred at r.t. for 2 h. Ethyl acetate was then added and the organic phase was washed with saturated aqueous NH4Cl, H2O and brine, dried (MgSO4) and evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (65:35) afforded the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05527827 |
| 출처 데이터셋 | uspto-grants-1996_06 |
| ORD ID | ord-f263892467124d7491ef5fa10b99c9fb |
| 출처 메모 | uspto-grants-1996_06 |