2-Chloro-4-cyanopyridine → 2-Methoxyisonicotinonitrile

HRID 260471

반응식

HRID 260471 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[CH3:10][O-:11].[Na+]>CO>[C:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([O:11][CH3:10])[CH:7]=1)#[N:9]

참가 물질

4

반응물 2

HCID 5686382-Chloro-4-cyanopyridineHCID 10942334Sodium Methoxide

생성물 1

HCID 72048872-Methoxyisonicotinonitrile

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-chloro-4-cyanopyridine (1.25 g, 9.1 mmol), prepared as described by D. Libermann, N. Rist, F. Grumbach, S. Cals, M. Moyeux and A. Rouaix, Bull. Soc. Chim. France, 694 (1958), in methanol was treated with sodium methoxide (0.58 g, 10.9 mmol) and refluxed for 30 minutes. The reaction mixture was cooled, filtered and the filtrate concentrated in vacuo to obtain the crude product as an off-white solid. The crude product was chromatographed on silica gel with 20% ethyl acetate in hexane. The title compound was obtained as a white powder.

후처리

  1. temperaturerefluxed for 30 minutes
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated in vacuo
  5. customto obtain the crude product as an off-white solid
  6. customThe crude product was chromatographed on silica gel with 20% ethyl acetate in hexane

출처 및 근거

ORD 기록
ord-45dee7e4a0c54f2d8932178cdf3a380e
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527819

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