Ammonium Chloride → 3-Benzenesulfonyl-5-chloroindole-2-carboxamide

HRID 260479노트

반응식

HRID 260479 반응식
[C:1]1([S:7]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=3)[NH:12][C:11]=2[C:20]([O:22]CC)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[NH4+:26]>[OH-].[NH4+]>[C:1]1([S:7]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:19])[CH:17]=3)[NH:12][C:11]=2[C:20]([NH2:26])=[O:22])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 25517Ammonium ChlorideHCID 22401503Ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate

생성물 1

HCID 4548443-Benzenesulfonyl-5-chloroindole-2-carboxamide

시약·촉매·용매 1

HCID 14923Ammonium Hydroxide용매

반응 조건

온도
100 °C

실험 절차

A suspension of ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate (596 mg, 1.64 mmol) in aqueous conc. ammonium hydroxide (10 mL) containing ammonium chloride (28 mg) was heated at 100° C. for 3 hours in a sealed screw-top tube. The sealed tube was cooled in an ice bath as product crystallized out. The product was collected by filtration, rinsed with ice water, and dried to give the product, mp 253°-254° C.

후처리

  1. temperatureThe sealed tube was cooled in an ice bath as product
  2. customcrystallized out
  3. filtrationThe product was collected by filtration
  4. washrinsed with ice water
  5. customdried
  6. customto give the product, mp 253°-254° C.

출처 및 근거

ORD 기록
ord-1938ad879d994b299f62cfe8700855bb
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527819

반응 노트

불러오는 중…