3-Benzenesulfonyl-5-chloroindole-2-carboxamide → 5-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

HRID 260494노트

반응식

HRID 260494 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH2:13])=O)=[C:5]2[S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:16])=[O:15].[OH-].CCC[N+](S(=O)(=O)NC(O)=O)(CC)CC>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]#[N:13])=[C:5]2[S:14]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)(=[O:16])=[O:15]

참가 물질

4

반응물 2

HCID 4548443-Benzenesulfonyl-5-chloroindole-2-carboxamideHCID 86749577Methyl (carboxysulfamoyl)triethylammonium hydroxide

생성물 1

HCID 224015145-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5-Chloro-3-phenylsulfonylindole-2-carboxamide reacts with methyl (carboxysulfamoyl)triethylammonium hydroxide inner salt (Burgess reagent) in tetrahydrofuran (THF) solvent as described by D. A. Claremon and B. T. Phillips (Tetrahedron Lett., 29, 2155 (1988)) to provide the title compound.

출처 및 근거

ORD 기록
ord-0b1fe20c76aa419b99e691b77546a0e6
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527819

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