Cyanamide → 3-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine

HRID 260496노트

반응식

HRID 260496 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11](=[NH:15])OCC)=[C:5]2[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17].[N:25]#[C:26][NH2:27]>CO>[C:26]([NH:27][C:11]([C:6]1[NH:7][C:8]2[C:4]([C:5]=1[S:16]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(=[O:18])=[O:17])=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)=[NH:15])#[N:25]

참가 물질

4

반응물 2

HCID 9864CyanamideHCID 135761968Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate

생성물 1

HCID 1785123053-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate is reacted with an equimolar amount of cyanamide in absolute methanol (according to the procedure of K. R. Huffman and F. C. Schaefer (J. Org. Chem., 28, 1812 (1963)). After 30-60 minutes the solvent is removed and the residue purified by silica gel chromatography to afford the title compound.

후처리

  1. customAfter 30-60 minutes the solvent is removed
  2. customthe residue purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-137b4c1d36df4ac9a6d032cd522cafed
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527819

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