Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon Dioxide → 1-(Tol-4-yl)3,4-dihydro-4,4-dimethyl-7-naphthaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon Dioxide | HCID 280 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Pentane | HCID 8003 | — |
| 반응물 | 6-Bromo-1,1-dimethyl-4-p-tolyl-1,2-dihydronaphthalene | HCID 10687622 | — |
| 반응물 | HCID 178418306 | HCID 178418306 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(Tol-4-yl)3,4-dihydro-4,4-dimethyl-7-naphthaldehyde | HCID 86588677 | — |
반응 단계
To a cold (-78° C.), stirred solution of 1-(tol-4-yl)3,4-dihydro-4,4-dimethyl-7-bromo-naphthalene (Compound B 1 g, 3.2 mmol), in THF (17 mL) was added t-BuLi in pentane (1.7M solution, 3 mL, 5.1 mmol). After 10 minutes dry dimethylformamide (DMF) (600 mg, 8 mmol) was added and the dry-ice cooling was replaced with ice-water bath. The mixture was gradually warmed to ambient temperature and diluted with ethylacetate (150 mL), washed with water (15 mL). The organic layer was dried with MgSO4 and solvent was removed under reduced pressure. The crude material was purified by silicagel chromatography to afford the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728846 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-bf0cea00f0c14b87bedbeafd627d9061 |
| 출처 메모 | uspto-grants-1998_03 |