Methanol → 1-Bromo-4-(dimethoxymethyl)benzene

HRID 260537

반응식

HRID 260537 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH:10]([O-])([O-])[O:11]C.[CH3:15]O>C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]([O:11][CH3:10])[O:7][CH3:15])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 707414-BromobenzaldehydeHCID 53629101Methylorthoformate

생성물 1

HCID 6883421-Bromo-4-(dimethoxymethyl)benzene

시약·촉매·용매 1

HCID 6101p-Toluenesulfonic acid촉매

실험 절차

A mixture of 4-bromobenzaldehyde (21.9 g, 120 mmol), methyl orthoformate (50 mL, 457 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 100 mL of methanol was heated under reflux for 5 hours. The solvent was removed under vacuum and distillation of the remaining residue gave 1-bromo-4-(dimethoxymethyl)benzene (2.24 g, 9.7 mmol) as a clear colorless oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe solvent was removed under vacuum and distillation of the remaining residue

출처 및 근거

ORD 기록
ord-178afc60c87546ecabfd891ac31edc83
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05527918

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