1-Benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-1,2,5,6-tetrahydropyridine → 3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine

HRID 26065노트

반응식

HRID 26065 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:28])([CH3:27])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:16][C:15]=2[O:29]CC2C=CC=CC=2)[CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[CH3:28][C:20]([C:17]1[CH:18]=[CH:19][C:14]([CH:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[C:15]([OH:29])[CH:16]=1)([CH3:27])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

5

반응물 2

HCID 204997811-Benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-1,2,5,6-tetrahydropyridineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 155715583-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine수율 42%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4.2 g. (8.73 mmols) of 1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-1,2,5,6-tetrahydropyridine, 4.0 g. of 10% palladium-on-carbon and 50 ml. of ethanol is stirred under one atmosphere of hydrogen for 2 hours. The reaction mixture is filtered through diatomaceous earth with ethyl acetate, evaporated and the residue again dissolved in ethyl acetate and filtered. The filtrate is evaporated and the residue crystallized in ether to yield 1.1 g. (42%) of the title compound.

후처리

  1. additionA mixture of 4.2 g
  2. filtrationThe reaction mixture is filtered through diatomaceous earth with ethyl acetate
  3. customevaporated
  4. dissolutionthe residue again dissolved in ethyl acetate
  5. filtrationfiltered
  6. customThe filtrate is evaporated
  7. customthe residue crystallized in ether
  8. customto yield 1.1 g

출처 및 근거

ORD 기록
ord-79aafa1cc7214830822e6fe078a7bad2
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147872

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