Potassium Hydroxide → 4H,5H,6H-cyclopenta[c]thiophene-5-carboxylic acid
반응식
[C:1]([CH:6]1[CH2:13][C:9]2=[CH:10][S:11][CH:12]=[C:8]2[CH2:7]1)([O:3]CC)=[O:2].[OH-].[K+]>C(O)C.O>[C:1]([CH:6]1[CH2:13][C:9]2=[CH:10][S:11][CH:12]=[C:8]2[CH2:7]1)([OH:3])=[O:2]참가 물질
5
실험 절차
Dissolve 5-(carboethoxy)-2,4,5,6-tetrahydrocyclopenta[c]thiophene (6.68 g, 34.1 mmol) in ethanol (95%, 150 mL) and water (75 mL). Add potassium hydroxide (9.5 g, 0.17mol) and stir at room temperature for 1 hour. Partition between water (150 mL) and ethyl ether (2×150 mL). Acidify the aqueous phase with hydrochloric acid to pH 1. Extract with methylene chloride (2×150 mL), dry (Na2SO4) and evaporate the solvent in vacuo to give 5-(carboxy)-2,4,5,6-tetrahydrocyclopenta [c]thiophene.
후처리
- customPartition between water (150 mL) and ethyl ether (2×150 mL)
- extractionExtract with methylene chloride (2×150 mL)
- dry with materialdry (Na2SO4)
- customevaporate the solvent in vacuo
출처 및 근거
- ORD 기록
- ord-ce5ff01320c24c62b0db101bd83e08c4
- 출처 데이터셋
- uspto-grants-1996_06
- 특허 번호
- US05529996
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