Tetrahydrofuran → HCID 178476926, 화합물

HRID 261014

반응식

HRID 261014 반응식
C([NH:4][C:5]([C:7]1[C:12]([NH2:13])=[N:11][C:10]([NH:14][CH:15]([CH3:17])[CH3:16])=[C:9]([Cl:18])[N:8]=1)=[O:6])(=N)N.C1C[N:26]2[C:21](=[N:22]CCC2)C1.[P:28](Cl)([O:32][CH2:33][CH3:34])[O:29][CH2:30][CH3:31].[O:36]1CCCC1>>[NH2:13][C:12]1[C:7]([C:5]([NH:4][N:22]=[CH:21][NH:26][P:28](=[O:36])([O:32][CH2:33][CH3:34])[O:29][CH2:30][CH3:31])=[O:6])=[N:8][C:9]([Cl:18])=[C:10]([NH:14][CH:15]([CH3:16])[CH3:17])[N:11]=1

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 68530Ethyl phosphorochloriditeHCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 178456870HCID 178456870, 화합물

생성물 1

HCID 178476926HCID 178476926, 화합물

실험 절차

A stirred solution of N-amidino-3-amino-5-isopropylamino-6-chloropyrazinecarboxamide (2.7 g., 0.01 mole) and DBN (1.24 g., 0.01 mole) in tetrahydrofuran (100 ml.) is cooled to 10° C., treated with diethyl chlorophosphite (1.44 ml., 0.01 mole), then stirred at 25° for one hour. The reaction mixture is filtered evaporated to a volume of 5 ml. and treated with water (100 ml.) to give diethyl N-[(3-amino-6-chloro-5-isopropylaminopyrazinamido)iminomethyl]phosphoramidate which melts at 166° C. after recrystallization from isopropanol-water.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customevaporated to a volume of 5 ml
  3. additionand treated with water (100 ml.)

출처 및 근거

ORD 기록
ord-f07c74b63ac943b38617228690a00d48
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163781

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