참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Ethyl phosphorochloridite | HCID 68530 | — |
| 반응물 | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| 반응물 | HCID 178513083 | HCID 178513083 | — |
| 생성물 | HCID 178476927 | HCID 178476927 | — |
반응 단계
A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (300 ml.) is cooled to 10° C. and treated with diethyl chlorophosphite (2.9 ml., 0.02 mole). The reaction is stirred at 25° C. for 3 hours, filtered and treated with ice water (300 ml.) to give diethyl N-[(3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 230° C. after recrystallization from ethanol-water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04163781 |
|---|
| 출처 데이터셋 | uspto-grants-1979_08 |
|---|
| ORD ID | ord-960ab3d9ab704cd8b07c05ab4008cd5d |
|---|
| 출처 메모 | uspto-grants-1979_08 |
|---|
