Ammonia → HCID 178419104, 화합물

HRID 261059노트

반응식

HRID 261059 반응식
Cl.[C:2](=[NH:9])(OCC)[CH:3]([CH3:5])[CH3:4].[NH3:10].[OH2:11].[C:12]1([CH3:18])[CH:17]=[CH:16]C=CC=1>CN(C)C>[CH:3]([C:2]1[N:9]=[C:12]([CH3:18])[CH:17]=[C:16]([OH:11])[N:10]=1)([CH3:5])[CH3:4]

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 1140Toluene2회HCID 12816252Ethyl 2-methylpropanimidate--hydrogen chloride (1/1)

생성물 1

HCID 178419104HCID 178419104, 화합물

시약·촉매·용매 1

HCID 1146Trimethylamine용매2회

실험 절차

The method according to claim 1 wherein ethyl isobutyrimidate hydrochloride is neutralized by trimethylamine dissolved in toluene, the free ethyl isobutyrimidate is freed from water by azeotropic distillation; then the dry ethyl isobutyrimidate in toluene is reacted with an excess of diketene dissolved in toluene in the presence of trimethylamine and the resulting organic solution is treated with gaseous ammonia, in molar equivalent amounts and subsequent azeotropic removal of water to form 2-isopropyl-4-methyl-6-hydroxypyrimidine which is dried and recovered from said organic solvent.

후처리

  1. distillationthe free ethyl isobutyrimidate is freed from water by azeotropic distillation
  2. customthen the dry ethyl isobutyrimidate in toluene is reacted with an excess of diketene

출처 및 근거

ORD 기록
ord-d986d003f8234d2b8dbbaac6d7f06df9
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163848

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