2,6-Dichloropyrazine → 4-(6-Chloropyrazin-2-yl)piperazin-2-one

HRID 261060노트

반응식

HRID 261060 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[O:9]=[C:10]1[CH2:15][NH:14][CH2:13][CH2:12][NH:11]1>C(#N)C>[Cl:8][C:4]1[N:3]=[C:2]([N:14]2[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH2:15]2)[CH:7]=[N:6][CH:5]=1

참가 물질

4

반응물 2

HCID 785042,6-DichloropyrazineHCID 231360Piperazin-2-one

생성물 1

HCID 203960024-(6-Chloropyrazin-2-yl)piperazin-2-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 10.0 g (0.0067 mole) of 2,6-dichloropyrazine and 14 g (0.14 mole) of 2-oxopiperazine in 100 ml of acetonitrile is refluxed 1.5 hour with stirring under N2. The mixture is concentrated under vacuum, the residue titrated with water and filtered, and the crude solid recrystallized from water (charcoal treatment) to give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

후처리

  1. temperatureis refluxed 1.5 hour
  2. concentrationThe mixture is concentrated under vacuum
  3. filtrationfiltered
  4. customthe crude solid recrystallized from water (charcoal treatment)
  5. customto give off-white plates of the subject compound, 7.7 g, mp 192°-193° C.

출처 및 근거

ORD 기록
ord-fbaa38e21c5b4138988186de4e3cf619
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163849

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