참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Cyanophenol | HCID 13019 | — |
| 반응물 | 4H,5H,6H,7H-thieno(2,3-c)pyridine | HCID 12337025 | — |
| 반응물 | HCID 178486302 | HCID 178486302 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Isopropyl alcohol isopropyl ether | HCID 21202047 | 23% |
반응 단계
A mixture of 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (1 g; 7.2 mmoles), p-cyano-phenol (95% purity; 0.9 g; 7.2 mmoles), polyoxymethylene (0.43 g; 14.4 mmoles) and dioxan (20 cc) is stirred at 80° C. during 4 hours. After concentration in vacuo, the residue is taken up into 2N hydrochloric acid. The aqueous phase is extracted with ether, made basic with concentrated ammonia and again extracted with methylene chloride. The organic extracts are washed with water, dried over sodium sulfate and concentrated in vacuo. The residue is recrystallized from isopropyl ether-isopropanol (M.p. 134° C.; yield: 23%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04163852 |
|---|
| 출처 데이터셋 | uspto-grants-1979_08 |
|---|
| ORD ID | ord-7fefc21f9657424996b491b80f457b88 |
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| 출처 메모 | uspto-grants-1979_08 |
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