Acetonitrile → 1-Benzyl-6-chloroimidazo[1,2-a]pyridinium bromide

HRID 261115노트

반응식

HRID 261115 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(#N)C>C(OCC)C>[Br-:11].[CH2:12]([N+:10]1[CH:9]=[CH:8][N:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=12)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 7498Benzyl BromideHCID 27643286-Chloroimidazo(1,2-a)pyridine

생성물 1

HCID 203955731-Benzyl-6-chloroimidazo[1,2-a]pyridinium bromide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 2.3 g. of 6-chloroimidazo[1,2-a]pyridine and 3.42 g. of α-bromotoluene in 40 ml. of dry acetonitrile is heated at reflux temperatures overnight. The solution is cooled and 35 ml. of diethyl ether added. The precipitated solids are collected and twice recrystallized from isopropanol-diethyl ether, 3.8 g., m.p. 193°-195° C.

후처리

  1. temperatureat reflux temperatures overnight
  2. temperatureThe solution is cooled
  3. customThe precipitated solids are collected
  4. customtwice recrystallized from isopropanol-diethyl ether, 3.8 g

출처 및 근거

ORD 기록
ord-0acab4bbb1c44328b8b7d4b097046ffd
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04163745

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