Diethylcarbamoyl chloride → 1-Diethylcarbamoyl-3-diallylsulphamoyl-1,2,4-triazole

HRID 26116

반응식

HRID 26116 반응식
[CH2:1]([N:4]([CH2:13][CH:14]=[CH2:15])[S:5]([C:8]1[N:12]=[CH:11][NH:10][N:9]=1)(=[O:7])=[O:6])[CH:2]=[CH2:3].[CH2:16]([N:18]([CH2:22][CH3:23])[C:19](Cl)=[O:20])[CH3:17].C(N(CC)CC)C>O1CCCC1>[CH2:16]([N:18]([CH2:22][CH3:23])[C:19]([N:10]1[CH:11]=[N:12][C:8]([S:5](=[O:7])(=[O:6])[N:4]([CH2:1][CH:2]=[CH2:3])[CH2:13][CH:14]=[CH2:15])=[N:9]1)=[O:20])[CH3:17]

참가 물질

5

반응물 3

HCID 6916Diethylcarbamoyl chlorideHCID 8471TriethylamineHCID 178457344HCID 178457344, 화합물

생성물 1

HCID 213242681-Diethylcarbamoyl-3-diallylsulphamoyl-1,2,4-triazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 6.9 g. 3-diallylsulphamoyl-1,2,4-triazole, 4.5 g. diethylcarbamoyl chloride, 6ml. triethylamine and 25 ml. dry tetrahydrofuran was refluxed under anhydrous conditions for 1.5 hours. The cooled reaction mixture was filtered to remove triethylamine hydrochloride and the filtrate was evaporated to remove solvent. The solid residue was recrystallized from petroleum ether, b.p. 60°-80° C., to give 1-diethylcarbamoyl-3-diallylsulphamoyl-1,2,4-triazole, m.p. 49°-51° C. Elemental analysis satisfactory.

후처리

  1. additionA mixture of 6.9 g
  2. customThe cooled reaction mixture
  3. filtrationwas filtered
  4. customto remove triethylamine hydrochloride
  5. customthe filtrate was evaporated
  6. customto remove solvent
  7. customThe solid residue was recrystallized from petroleum ether, b.p. 60°-80° C.

출처 및 근거

ORD 기록
ord-4267794288414405abf990af1d5262c8
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148626

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