Acetaminophen → {4-[(2,4-Dichlorobenzyl)oxy]phenyl}amine

반응식

[OH:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6]C(=O)C)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:14]=1[CH2:15]Cl.[O-]CC.[Na+].[OH-].[K+]>C(O)C>[Cl:12][C:13]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:14]=1[CH2:15][O:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:6])=[CH:10][CH:11]=1

참가 물질

실험 절차

In ethanol, p-hydroxyacetoanilide is reacted with 2,4-dichlorobenzyl chloride in the presence of sodium ethoxide and the resultant 4-(2,4-dichlorobenzyloxy)-acetoanilide is treated with potassium hydroxide in ethanol, whereby 4-(2,4-dichlorobenzyloxy)-aniline is obtained as crystals melting at 70°-71° C. In a similar manner, the following compounds can be prepared from the corresponding substituted benzyl halide derivatives.