Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propanenitrile, 3-(methylamino)- → 3-[N-(p-chlorocinnamyl)-methylamino]propionitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propanenitrile, 3-(methylamino)- | HCID 69656 | — |
| 반응물 | p-Chlorocinnamyl bromide | HCID 53877224 | — |
| 촉매 | Benzenemethanaminium, N,N,N-tributyl-, bromide | HCID 2724282 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 3-[N-(p-chlorocinnamyl)-methylamino]propionitrile | HCID 54351008 | — |
반응 단계
A solution of 116 g of p-chlorocinnamyl bromide in 500 ml of methylene chloride is added dropwise with stirring to a mixture of 42 g of 3-methylamino-propionitrile and 8.9 g of benzyl-tri-(n-butyl)ammonium bromide in 1 liter of methylene chloride and 500 ml of 2 N sodium hydroxide solution at room temperature and under a nitrogen atmosphere, and the emulsion stirred for 65 hours at room temperature. The organic phase is separated, washed with water, dried over sodium sulphate and evaporated to yield 3-[N-(p-chlorocinnamyl)-methylamino]-propionitrile. M.P. 143° [hydrogen oxalate form]
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04164583 |
| 출처 데이터셋 | uspto-grants-1979_08 |
| ORD ID | ord-e42bef5d4dd8458b8cd112224d2d9d0c |
| 출처 메모 | uspto-grants-1979_08 |