Propynamide → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxamide

HRID 261211

반응식

HRID 261211 반응식
[N+:1](=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12])=[N-:2].[C:13]([NH2:17])(=[O:16])[C:14]#[CH:15]>C1C=CC=CC=1>[O:12]=[C:4]1[N:1]2[N:2]=[C:14]([C:13]([NH2:17])=[O:16])[CH:15]=[C:3]2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[NH:5]1

참가 물질

4

반응물 2

HCID 101445PropynamideHCID 136455454(3Z)-3-diazo-1H-indol-2-one

생성물 1

HCID 1357356155,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxamide수율 13.1%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

4.8 g (0.03 mole) of 3-diazooxindole and 2.4 g (0.035 mole) of the propiolamide are taken up in benzene (250 ml) and refluxed overnight under a stream of nitrogen. The light tan precipitates that form are filtered off and dried in a vacuum oven for 4 hours. Yield 4.4 g. Additional refluxing of the filtrate gives 900 mg of product. Total yield: 5.3 g (77.4%).

후처리

  1. temperaturerefluxed overnight under a stream of nitrogen
  2. customThe light tan precipitates that form
  3. filtrationare filtered off
  4. customdried in a vacuum oven for 4 hours
  5. temperatureAdditional refluxing of the filtrate

출처 및 근거

ORD 기록
ord-6f140fc08bbf4a5d8cf0c8fccf969780
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04164578

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