2-Propynenitrile → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonitrile

HRID 261213

반응식

HRID 261213 반응식
[N+:1](=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12])=[N-:2].[C:13]([C:15]#[CH:16])#[N:14]>C1C=CC=CC=1>[O:12]=[C:4]1[N:1]2[N:2]=[C:15]([C:13]#[N:14])[CH:16]=[C:3]2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[NH:5]1

참가 물질

4

반응물 2

HCID 140552-PropynenitrileHCID 136455454(3Z)-3-diazo-1H-indol-2-one

생성물 1

HCID 1357356215,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonitrile

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

6.0 g (0.04 mole) of 3-diazooxindole and 2.2 g (0.045 mole) of cyanoacetylene are taken up in benzene (250 ml) and refluxed overnight under N2. The mixture is cooled and the beige-colored precipitates are filtered off. The crude product is dried in a vacuum oven at room temperature for 3 hours. Yield: 5.2 g, m.p. 302°-304°. Percent yield: 65.6.

후처리

  1. temperaturerefluxed overnight under N2
  2. temperatureThe mixture is cooled
  3. customthe beige-colored precipitates
  4. filtrationare filtered off
  5. dry with materialThe crude product is dried in a vacuum oven at room temperature for 3 hours

출처 및 근거

ORD 기록
ord-3ae42d3aa8164d47bb75f4c78bb238b5
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04164578

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