Triethylamine → HCID 178471604, 화합물

HRID 26128

반응식

HRID 26128 반응식
C(N(CC)CC)C.Cl.[NH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14].Cl[C:19]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[S:21](=[O:29])(=[O:28])[N:20]=1>O1CCOCC1>[O:28]=[S:21]1(=[O:29])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:19]([NH:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:20]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 64783Pseudosaccharin chlorideHCID 126496614-Aminobutyrate ethyl hydrochloride

생성물 1

HCID 178471604HCID 178471604, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4.07 ml (29.2 mM) of triethylamine is added to 5.0 g. (29.2 mM) of ethyl 4-aminobutyrate hydrochloride, suspended in 75 ml of dioxane. After stirring for 5 minutes, 5.88 g. (29.2 mM) of 3-chloro-1,2-benzisothiazole 1,1-dioxide is added and the mixture is refluxed for one hour. The solvent is evaporated in vacuo and the residue is taken up in chloroform, washed with water, and evaporated to dryness. The residual 4-[(1,1-dioxo-1,2-benzisothiazol-3-yl)amino]-butanoic acid, ethyl ester is recrystallized from 40 ml. of methanol/water, yield 3.72 g., m.p. 125°-127°.

후처리

  1. temperaturethe mixture is refluxed for one hour
  2. customThe solvent is evaporated in vacuo
  3. washwashed with water
  4. customevaporated to dryness
  5. customThe residual 4-[(1,1-dioxo-1,2-benzisothiazol-3-yl)amino]-butanoic acid, ethyl ester is recrystallized from 40 ml

출처 및 근거

ORD 기록
ord-2073cfa5dfc644b1b7a11fd14d15da28
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04148798

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