1,1,2-Trichloroethane → p-Nitrobenzyl 3-Methyl-2-(2-chlorosulfinyl-4-oxo-3-formamido-1-azetidinyl)-3-butenoate

HRID 261309

반응식

HRID 261309 반응식
[CH:1]([NH:3][C@@H:4]1[C:26](=[O:27])[N:6]2[CH:7]([C:13]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[O:14])[C:8]([CH3:12])([CH3:11])[S:9](=[O:10])[C@H:5]12)=[O:2].[Cl:28]N1C(=O)CCC1=O.ClC(Cl)CCl>>[CH3:11][C:8](=[CH2:12])[CH:7]([N:6]1[C:26](=[O:27])[CH:4]([NH:3][CH:1]=[O:2])[CH:5]1[S:9]([Cl:28])=[O:10])[C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1)=[O:14]

참가 물질

4

반응물 3

HCID 65741,1,2-TrichloroethaneHCID 31398ChlorosuccinimideHCID 86735569HCID 86735569, 화합물

생성물 1

HCID 20349500p-Nitrobenzyl 3-Methyl-2-(2-chlorosulfinyl-4-oxo-3-formamido-1-azetidinyl)-3-butenoate

실험 절차

A solution of 1.43 g. of p-nitrobenzyl 6β-formamido-2,2-dimethylpenam-3-carboxylate-1-oxide and 500 mg. of N-chlorosuccinimide in 40 ml. of dry 1,1,2-trichlorethane was refluxed for 90 minutes. The mixture was cooled, washed with water and brine, dried over MgSO4, and the solvent was evaporated. The nmr spectrum indicates conversion to the title compound.

후처리

  1. temperatureThe mixture was cooled
  2. washwashed with water and brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-7469e65a2f0643afa14c6488b4136a31
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04165315

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