Methyl isothiocyanate → HCID 178486109, 화합물

HRID 261433노트

반응식

HRID 261433 반응식
[NH:1]([C:5]1[NH:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:15][N:16]=[C:17]=[S:18]>C(O)C>[NH:1]([C:5]1[NH:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:17]([NH:16][CH3:15])=[S:18])[N:9]=1)[C:2]([NH2:4])=[NH:3]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 1785126412-Guanidino-4-(4-aminobutyl)imidazole

생성물 1

HCID 178486109HCID 178486109, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-guanidino-4-(4-aminobutyl)imidazole (0.15 g.) and methylisothiocyanate (0.1 g.) in ethanol (10 ml.) was stirred overnight and then evaporated to dryness. The residue was purified by chromatography on a silica gel column using chloroform/methanol/ammonia (s.g. 0.880) 80:20:0.3 v/v/v. The appropriate fractions on evaporation gave a gum which crystallized on triturating in petroleum ether (b.p. 40°-60° C.) to give 2-guanidino-4-[4-(3-methylthioureido)butyl]imidazole, m.p. 179°-184° C.

후처리

  1. customevaporated to dryness
  2. customThe residue was purified by chromatography on a silica gel column
  3. customThe appropriate fractions on evaporation
  4. customgave a gum which
  5. customcrystallized
  6. customon triturating in petroleum ether (b.p. 40°-60° C.)

출처 및 근거

ORD 기록
ord-ca8ed7eb01d8480c8e80ec7037ba8586
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04165377

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