N-Phenylphthalimide → 2,3-Dihydro-2-phenyl-1H-isoindol-1-one

HRID 261522

반응식

HRID 261522 반응식
[C:1]1([N:7]2[C:11](=O)[C:10]3=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]3[C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Zn].C(O)(=O)C>[CH2:11]1[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:17])[C:9]2[C:10]1=[CH:13][CH:14]=[CH:15][CH:16]=2

참가 물질

4

반응물 1

HCID 68215N-Phenylphthalimide

생성물 1

HCID 970352,3-Dihydro-2-phenyl-1H-isoindol-1-one수율 78%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

A mixture of N-phenylphthalimide (100 g), zinc powder (147 g) and acetic acid (700 ml) is heated under reflux for 5.5 hours with stirring. After cooling, the mixture is filtered and the insoluble solid is washed with hot acetic acid (100 ml). The combined filtrate and washings are concentrated to give crystal (72 g, 78%). Recrystallization from benzene gives colorless scales. Melting point: 166° to 167° C.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 5.5 hours
  3. temperatureAfter cooling
  4. filtrationthe mixture is filtered
  5. washthe insoluble solid is washed with hot acetic acid (100 ml)
  6. concentrationThe combined filtrate and washings are concentrated

출처 및 근거

ORD 기록
ord-45d7bbf4da3a4ad8808211dd6c270b8c
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166125

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