alpha-Ethyl-alpha-methyl-dihydrocinnamic acid → 2-Ethyl-2-methyl-1-indanone

HRID 261528

반응식

HRID 261528 반응식
[CH2:1]([C:3]([CH3:14])([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([OH:6])=O)[CH3:2]>O>[CH2:1]([C:3]1([CH3:14])[CH2:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:6])[CH3:2]

참가 물질

3

반응물 1

HCID 20394459alpha-Ethyl-alpha-methyl-dihydrocinnamic acid

생성물 1

HCID 146860942-Ethyl-2-methyl-1-indanone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

69 g of α-ethyl-α-methyl-dihydrocinnamic acid are added dropwise at 150°, within 5 minutes, to 700 g of polyphosphoric acid, while stirring. The reaction mixture is stirred at 160° for a further 10 minutes, is cooled to 100° and 100 cc of water are added dropwise. The reaction mixture is then poured on ice, extracted with ether, the ether extract is washed with water and dried over sodium sulphate. The 2-ethyl-2-methyl-1-indanone, obtained after evaporating the solvent, is purified by distillation. B.P. 137°-140° at 20 mm of Hg.

후처리

  1. stirringThe reaction mixture is stirred at 160° for a further 10 minutes
  2. temperatureis cooled to 100°
  3. additionThe reaction mixture is then poured on ice
  4. extractionextracted with ether
  5. extractionthe ether extract
  6. washis washed with water
  7. dry with materialdried over sodium sulphate

출처 및 근거

ORD 기록
ord-d280e6f49a1b4e39adc6e5d503e9626b
출처 데이터셋
uspto-grants-1979_08
특허 번호
US04166131

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