Metaperiodic acid → 3-Chloro-4-cyclohexylbenzaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([OH:17])CO)[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.I(O)(=O)(=O)=O>O1CCCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1)[CH:14]=[O:17]참가 물질
5
실험 절차
To 115 g. of 1-(3-chloro-4-cyclohexylphenyl)-1,2-ethanediol in tetrahydrofuran (800 ml.) is added a solution of periodic acid (102 g.) in ether (750 ml.). The reaction mixture is stirred under nitrogen overnight. The reaction mixture is filtered and the filtrate is washed with water (3×200 ml) and placed over sodium sulfate. Removal of solvent gives a liquid residue which is then distilled to give 3-chloro-4-cyclohexylbenzaldehyde.
후처리
- filtrationThe reaction mixture is filtered
- washthe filtrate is washed with water (3×200 ml)
- customRemoval of solvent
- customgives a liquid residue which
- distillationis then distilled
출처 및 근거
- ORD 기록
- ord-bd3d48e15ff34669857d860640d41bc3
- 출처 데이터셋
- uspto-grants-1979_08
- 특허 번호
- US04166133
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