Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
UP 614-04 → 2-(1-Phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | UP 614-04 | HCID 134375 | — |
| 반응물 | Maleic Acid | HCID 444266 | — |
| 반응물 | 4-Benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride | HCID 70601802 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(1-Phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate | HCID 86736081 | — |
반응 단계
30 g of 4-benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride are treated as in part (a) of Example 2. After evaporation of the solvent under reduced pressure, 20 g of an oily product are obtained and are dissolved in hot isopropyl alcohol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly, 19 g of 2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine maleate are obtained, m.p. 234° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04152434 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-b09a96f4040e4c838a7acfab84df7701 |
| 출처 메모 | uspto-grants-1979_05 |