Triethylamine → N-(5-Methyl-1,3,4-oxadiazol-2-yl)-N-propylcyclobutanecarboxamide

HRID 261800노트

반응식

HRID 261800 반응식
[CH3:1][C:2]1[O:6][C:5]([NH:7][CH2:8][CH2:9][CH3:10])=[N:4][N:3]=1.[CH:11]1([C:15](Cl)=[O:16])[CH2:14][CH2:13][CH2:12]1.C(N(CC)CC)C>C1C=CC=CC=1>[CH3:1][C:2]1[O:6][C:5]([N:7]([CH2:8][CH2:9][CH3:10])[C:15]([CH:11]2[CH2:14][CH2:13][CH2:12]2)=[O:16])=[N:4][N:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 541521435-Methyl-N-propyl-1,3,4-oxadiazol-2-amine2회

생성물 1

HCID 21315333N-(5-Methyl-1,3,4-oxadiazol-2-yl)-N-propylcyclobutanecarboxamide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

5-Methyl-2-n-propylamino 1,3,4-oxadiazole (6 g, 0.04 mol) prepared as in (b) above, was refluxed with cyclobutanecarboxylic acid chloride (5.5 g, 0.05 mol) in benzene (25 ml) in the presence of triethylamine (4.72 g, 0.05 mol) for 2 hours. The mixture was filtered and the filtrate washed with dilute HCl, saturated solution NaCHO3 and water; dried over magnesium sulphate, filtered, solvent evaporated off to yield a reddish brown liquid which was distilled twice in a vigreux flask to yield the title compound as a slightly pink liquid (b.p. 110°-111° C./0.27 mm Hg).

후처리

  1. filtrationThe mixture was filtered
  2. washthe filtrate washed with dilute HCl, saturated solution NaCHO3 and water
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customsolvent evaporated off
  6. customto yield a reddish brown liquid which
  7. distillationwas distilled twice in a vigreux flask

출처 및 근거

ORD 기록
ord-1261bc12795546f5a9356a7c45b3dae1
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152442

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