Ethyl oxoacetate → HCID 53767038, 화합물

반응식

SC1C(=O)C=CC=CC=1.SC1C2C=CC=CC=2C=CC(=O)C=1.[NH2:23][C:24]1[C:30]2[CH:31]=[N:32][CH:33]=[CH:34][C:29]=2[CH:28]=[CH:27][C:26](=[O:35])[CH:25]=1.[CH2:36]([O:38][C:39](=[O:42])[CH:40]=[O:41])[CH3:37]>>[CH2:36]([O:38][C:39](=[O:42])[C:40]([NH:23][C:24]1[C:30]2[CH:31]=[N:32][CH:33]=[CH:34][C:29]=2[CH:28]=[CH:27][C:26](=[O:35])[CH:25]=1)=[O:41])[CH3:37]

참가 물질

반응물 4

HCID 70211Ethyl oxoacetate

HCID 125576902-Sulfanylcyclohepta-2,4,6-trien-1-one

HCID 21321474HCID 21321474, 화합물

HCID 21321481HCID 21321481, 화합물

생성물 1

HCID 53767038HCID 53767038, 화합물

실험 절차

By following serially the procedures of Examples 1 and 2 but replacing 2-mercapto-2,4,6-cycloheptatrien-1-one with an equivalent amount of 5-mercapto-7H-benzocyclohepten-7-one, 9-amino-7H-cyclohepta[c]pyridin-7-one, 5-mercapto-3H-6,7-dihydrocyclobutacyclohepten-3-one, 1-ethylamino-3H-6,7,8,9,10,11-hexahydrocycloheptacycloocten-3-one and 5-mercapto-3H-6,7,8,9,10,11,12,13-octahydrocycloheptacyclodecen-3-one, the following compounds are obtained respectively: ](7-oxo-7H-benzocyclohepten-5-yl)thio]oxoacetic acid ethyl ester (I; R1, R5, and R6 =H; R2 =S--CO--COOC2H5 ; and R3 and R4 together form a --CH=CH--CH=CH-- chain), [(7-oxo-7H-cyclohepta[c]pyridin-9-yl)-amino]oxo-acetic acid ethyl ester (I; R1, R5 and R6 =H; R2 =NC2H5 --CO--COOC2H5 ; and R3 and R4 together form a --CH=CH--N=CH-- chain). [(3-oxo-3H-6,7-dihydrocyclobutacyclohepten-5-yl)thio]oxo-acetic acid ethyl ester (I; R1, R5 and R6 =H; R2 =S--CO--COOC2H5 ; and R3 and R4 together form a --CH2CH2 -- chain), [N-(3-oxo-3H-6,7,8,9,10,11-hexahydrocycloheptacycloocten-1-yl)ethylamino]oxo-acetic acid ethyl ester (I; R1, R2 and R6 =H; R3 and R4 together form a --(CH2)6 chain; and R5 =NC2H5 --CO--COOC2H5) and [(3-oxo-3H-6,7,8,9,10,11,12,13-octahydrocycloheptacyclodecen-5 -yl)thio]oxoacetic acid ethyl ester (I; R1, R5 and R6 =H; R2 =S--CO--COOC2H5 ; and R3 and R4 together form a --(CH2)8 -- chain).