alpha-(p-Fluorophenyl)-1-(methoxymethyl)-alpha-phenylimidazole-2-methanol → (4-fluorophenyl)(1H-imidazol-2-yl)phenylmethanol

HRID 261939

반응식

HRID 261939 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([C:10]2[N:11](COC)[CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.C(OCN1C=CN=C1C(C1C=CC(Cl)=CC=1)(C1C=CC=CC=1)O)C1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([C:10]2[NH:14][CH:13]=[CH:12][N:11]=2)[OH:9])=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 12433900alpha-(p-Fluorophenyl)-1-(methoxymethyl)-alpha-phenylimidazole-2-methanolHCID 124339151-[(Benzyloxy)methyl]-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol

생성물 1

HCID 12433859(4-fluorophenyl)(1H-imidazol-2-yl)phenylmethanol

실험 절차

Using the procedure described in Example VIC but substituting an equivalent amount of α-(p-fluorophenyl)-1-(methoxymethyl)-α-phenylimidazole-2-methanol for the 1-[(benzyloxy)methyl]-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol, α-(p-fluorophenyl)-α-phenylimidazole-2-methanol was obtained. Its melting point was 199-200.5° C. after crystallisation from acetone.

출처 및 근거

ORD 기록
ord-f00974106be14930821331b38229f7b6
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152441

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