Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Picric Acid → 1-Allyl-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Picric Acid | HCID 6954 | — |
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (4-chlorophenyl)(1H-imidazol-2-yl)phenylmethanol | HCID 12433863 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-Allyl-alpha-(p-chlorophenyl)-alpha-phenylimidazole-2-methanol | HCID 12433929 | — |
반응 단계
A mixture of 3.4 g (0.028 mol) of freshly distilled allyl bromide, 7 g (0.025 mol) of α-(p-chlorophenyl)-α-phenylimidazole-2-methanol (prepared according to Example IV), 1.2 g (0.030 mol) of sodium hydroxide, 0.050 g of picric acid and 50 ml. of acetonitrile was refluxed for 5 hours. The warm reaction mixture was filtered and water was added to the filtrate. The precipitate formed was filtered off, washed with water and petroleum ether (boiling range 40°-60° C.) and three times crystallised from isopropyl alcohol. 1-Allyl-α-(p-chlorophenyl)-α-phenylimidazole-2-methanol was obtained. Melting point 165°-165.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04152441 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-9019765763da459a8ba96ec7d4673355 |
| 출처 메모 | uspto-grants-1979_05 |