Water → Butanoic acid, 2-[(1-methylethoxy)imino]-3-oxo-, ethyl ester, (Z)-

HRID 261982노트

반응식

HRID 261982 반응식
C(=O)([O-])[O-].[K+].[K+].[C:7]([C:10](=[N:16][OH:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])(=[O:9])[CH3:8].I[CH:19]([CH3:21])[CH3:20].O>CC(C)=O.C(Cl)Cl>[C:7]([C:10](=[N:16][O:17][CH:19]([CH3:21])[CH3:20])[C:11]([O:13][CH2:14][CH3:15])=[O:12])(=[O:9])[CH3:8]

참가 물질

7

반응물 4

HCID 962WaterHCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 178472877HCID 178472877, 화합물

생성물 1

HCID 539498Butanoic acid, 2-[(1-methylethoxy)imino]-3-oxo-, ethyl ester, (Z)-

시약·촉매·용매 2

HCID 180Acetone용매HCID 6344Dichloromethane용매

실험 절차

52 g of potassium carbonate were added to a mixture of 397.8g of ethyl 2-acetyl-2-hydroxyiminoacetate in 200 ml of pure acetone cooled on an ice bath and then 25 ml of 2-iodopropane were added thereto over 25 minutes. The mixture was stirred for 2 hours and 800 ml of water and 500 ml of methylene chloride were added thereto. The mixture was stirred and decanted and the aqueous phase was extracted with methylene chloride. The mixture was dried and vacuum filtered and the filtrate was evaporated to obtain 41.5 g of ethyl 2-acetyl-2-(1-methylethoxyimino)-acetate.

후처리

  1. temperaturecooled on an ice bath
  2. stirringThe mixture was stirred
  3. customdecanted
  4. extractionthe aqueous phase was extracted with methylene chloride
  5. customThe mixture was dried
  6. filtrationvacuum filtered
  7. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-5bbf08768a9c4153848456c5d828f37e
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04152432

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