Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → N-[(1R,2R)-2-phenylcyclopentyl]azepan-2-imine;hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| 반응물 | rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride | HCID 70051154 | — |
| 촉매 | Ethanol | HCID 702 | — |
| 생성물 | N-[(1R,2R)-2-phenylcyclopentyl]azepan-2-imine;hydrochloride | HCID 145795653 | — |
반응 단계
A mixture of 4.0 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 205°-206° C. and 5.0 ml of O-methylcaprolactim was allowed to stand at room temperature for 6 days with occasional stirring. A few drops of ethanol were added to maintain a stirrable slurry, after which the mixture was cooled. The resulting solid was washed with ether and recrystallized from acetone/methanol to give the desired product, M.P. 181.5°-183.5° C. (dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04153235 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-d7a51cd389d24459ace4c698426a2e68 |
| 출처 메모 | uspto-grants-1979_05 |