O-Xylene → N-Methylenepyrrolidonyl-2-Cyclopentoxyaniline

HRID 262014

반응식

HRID 262014 반응식
[CH:1]1([O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[NH2:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.C([N:16]1[CH2:20][CH2:19][CH2:18][C:17]1=[O:21])O.[C:22]1(C)C(C)=CC=CC=1>O>[CH2:22]=[N:9][C:8]1[CH:10]=[CH:11][CH:12]=[C:13]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[C:7]=1[O:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 7237O-XyleneHCID 849112-Pyrrolidinone, 1-(hydroxymethyl)-HCID 64853982-(Cyclopentyloxy)aniline

생성물 1

HCID 70609772N-Methylenepyrrolidonyl-2-Cyclopentoxyaniline수율 51.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Cyclopentoxyaniline (10.0 g, 0.057 mole), N-methylolpyrrolidone (9.75 g, 0.85 mole) and xylene (25 cc) were refluxed under azeotropic conditions with the removal of 1.5 cc of water. The xylene was removed by rotary evaporation and the product was crystallized from 100 cc of hexane to yield 8.0 g (51.6%) of product, m.p. 87°-87.5° C.

후처리

  1. customThe xylene was removed by rotary evaporation
  2. customthe product was crystallized from 100 cc of hexane

출처 및 근거

ORD 기록
ord-620428e63c7243ba8d19feeb5620722f
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153446

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