Sodium Bicarbonate → Ethyl N-(2,3-dimethyl-2-isopropyl-1-oxobutyl)glycinate

HRID 262098노트

반응식

HRID 262098 반응식
C(=O)(O)[O-].[Na+].Cl.[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH2:12])[CH3:8].[CH3:14][C:15]([CH:22]([CH3:24])[CH3:23])([CH:19]([CH3:21])[CH3:20])[C:16](Cl)=[O:17]>O.CCOCC>[CH2:7]([O:9][C:10](=[O:13])[CH2:11][NH:12][C:16](=[O:17])[C:15]([CH3:14])([CH:22]([CH3:24])[CH3:23])[CH:19]([CH3:21])[CH3:20])[CH3:8]

참가 물질

6

반응물 3

HCID 516892Sodium BicarbonateHCID 2723640Glycine ethyl ester, hydrochlorideHCID 30166072,3-Dimethyl-2-isopropylbutyryl chloride

생성물 1

HCID 6452343Ethyl N-(2,3-dimethyl-2-isopropyl-1-oxobutyl)glycinate

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

Sodium bicarbonate (1.7g, 0.02 mole) and glycine ethyl ester hydrochloride (1.4g, 0.01 mole) were dissolved in water (10 ml) and a solution of 2,3-dimethyl-2-isopropylbutanoyl chloride (1.6g, 0.009 mole) in ether (10 ml) was added. The mixture was stirred vigorously at room temperature for 2 hours. After 16 hours at room temperature the ether layer was separated and dried (MgSO4). Removal of the solvent left a white solid which was recrystallised from ether/petroleum ether to give N-(2,3-dimethyl-2-isopropylbutanoyl)glycine ethyl ester, mp. 74.5°-75.5°.

후처리

  1. customAfter 16 hours at room temperature the ether layer was separated
  2. dry with materialdried (MgSO4)
  3. customRemoval of the solvent
  4. waitleft a white solid which
  5. customwas recrystallised from ether/petroleum ether

출처 및 근거

ORD 기록
ord-0a42cc2c5fea438787288d1ffeac5740
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153679

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