Tin tetrachloride → Ethyl4-[2,2-dimethyl-4-(5-methyl-thien-2-yl)-benzo[1,2-g]-chrom-3-en-7-yl]benzoate

HRID 2621

반응식

HRID 2621 반응식
C(OP([C:9](OC)(OC)[CH2:10][CH2:11][C:12]1[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=1)(OCC)=O)C.[Li]CCCC.[CH3:32][C:33]1([CH3:51])[CH:42]=[C:41]([C:43]2[S:44][C:45]([CH3:48])=[CH:46][CH:47]=2)[C:40]2[C:35](=[CH:36][CH:37]=[C:38]([CH:49]=O)[CH:39]=2)[O:34]1.Cl[Sn](Cl)(Cl)Cl>C1COCC1.CCCCCC.C(OCC)(=O)C.ClCCl>[CH2:19]([O:18][C:16](=[O:17])[C:15]1[CH:14]=[CH:13][C:12]([C:11]2[CH:49]=[CH:38][C:37]3[CH:36]=[C:35]4[C:40]([C:41]([C:43]5[S:44][C:45]([CH3:48])=[CH:46][CH:47]=5)=[CH:42][C:33]([CH3:51])([CH3:32])[O:34]4)=[CH:39][C:9]=3[CH:10]=2)=[CH:22][CH:21]=1)[CH3:20]

참가 물질

9

반응물 4

HCID 24287Tin tetrachlorideHCID 57037360Ethyl 4-(diethoxyphosphoryl-3,3-dimethoxypropyl)benzoate2회HCID 1317205762,2-Dimethyl-4(5-methyl-thien-2-yl)-chrom-3-en-6-al2회HCID 178418339Butyllithium

생성물 1

HCID 15887284Ethyl4-[2,2-dimethyl-4-(5-methyl-thien-2-yl)-benzo[1,2-g]-chrom-3-en-7-yl]benzoate

시약·촉매·용매 4

HCID 6344Dichloromethane용매2회HCID 8028Tetrahydrofuran용매2회HCID 8058Hexane용매HCID 8857Ethyl Acetate용매

실험 절차

To a cold (-78° C.) solution of ethyl 4-(diethoxyphosphoryl-3,3-dimethoxypropyl)benzoate (Compound D, 690 mg, 1.75 mmol) in THF (8 mL) was added n-BuLi in hexane (1.6M solution, 1.1 mL). The mixture was gradually warmed to ambient temperature over 30 min and stirred for 5 minutes. The mixture was recooled to -78° C. and 2,2-dimethyl-4(5-methyl-thien-2-yl)-chrom-3-en-6-al (Compound S, 300 mg, 1.1 mmol) in THF (1 mL) was added to the reaction mixture. The mixture was stirred at ambient temperature for 2 hours. The reaction mixture was diluted with ethyl acetate (100 mL) and washed with brine (10 mL) dried and the solvent was removed by evaporation. The material was subjected to flash chromatography on silica gel to obtain the E and Z olefinic compounds, which were dissolved in dichloromethane (5 mL) and cooled to -78° C. A solution of SnCl4 in dichloromethane (52 mg in 0.2 mL) was added to the olefinic compounds. The resulting mixture was stirred for 30 minutes, quenched with methanol, water and diluted with ethyl acetate (100 mL). The organic layer was washed with brine and dried. Solvent was removed under reduced pressure and purified by silicagel chromatography to afford the title compound as a white solid.

후처리

  1. customwas recooled to -78° C.
  2. stirringThe mixture was stirred at ambient temperature for 2 hours
  3. washwashed with brine (10 mL)
  4. customdried
  5. customthe solvent was removed by evaporation
  6. customto obtain the E and Z olefinic compounds, which
  7. temperaturecooled to -78° C
  8. stirringThe resulting mixture was stirred for 30 minutes
  9. customquenched with methanol, water
  10. additiondiluted with ethyl acetate (100 mL)
  11. washThe organic layer was washed with brine
  12. customdried
  13. customSolvent was removed under reduced pressure
  14. custompurified by silicagel chromatography

출처 및 근거

ORD 기록
ord-4fc614d343484a3da54bc68b788f4a1f
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728846

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