2-Propanone, 1-bromo-1-phenyl- → 2-(2-Chlorophenyl)-4-methyl-5-phenylthiazole

HRID 262127노트

반응식

HRID 262127 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3](=O)[CH3:4].[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([NH2:17])=[S:16]>C(O)C>[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]1[S:16][C:2]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[C:3]([CH3:4])[N:17]=1

참가 물질

4

반응물 2

HCID 908702-Propanone, 1-bromo-1-phenyl-HCID 27348242-Chlorothiobenzamide

생성물 1

HCID 203449802-(2-Chlorophenyl)-4-methyl-5-phenylthiazole수율 79.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-Bromo-1-phenyl-2-propanone (10.6g, 0.050 mole), o-chlorothiobenzamide (8.8g, 0.051 mole), and ethanol (100 ml) are mixed and, after the initial exothermic reaction has subsided, heated under reflux for two hours. The ethanol is evaporated and the residue is treated with chloroform and aqueous sodium bicarbonate. The chloroform layer is separated and evaporated to leave a yellow oil which solidifies on standing. Recrystallization from acetonitrile yields 11.3g (79%) of 2-(2-chlorophenyl)-4-methyl-5-phenylthiazole, m.p. 63°-65° C.

후처리

  1. customafter the initial exothermic reaction
  2. temperatureheated
  3. temperatureunder reflux for two hours
  4. customThe ethanol is evaporated
  5. additionthe residue is treated with chloroform and aqueous sodium bicarbonate
  6. customThe chloroform layer is separated
  7. customevaporated
  8. customto leave a yellow oil which
  9. customRecrystallization from acetonitrile

출처 및 근거

ORD 기록
ord-a2d9f3ac15984539875f6593735643a3
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153703

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