Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cysteamine → 4-Bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cysteamine | HCID 6058 | — |
| 반응물 | 4-Bromo-3-(bromomethyl)-1,2-thiazole | HCID 20557643 | — |
| 생성물 | 4-Bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide | HCID 20550098 | — |
반응 단계
The reaction of 4-bromo-3-(bromomethyl)isothiazole (8.5 g) with cysteamine (from cysteamine hydrochloride (3.76 g)) was performed under conditions similar to those described in Example 72. From the reaction there was obtained 4-bromo-3-[(2-aminoethyl)thiomethyl]isothiazole hydrobromide, which, following recrystallisation from ethanol-ether and acetonitrile, gave needles (4.05 g), m.p. 111°-112°. The amine base (2.73 g) was isolated by basification with sodium hydroxide and extraction with chloroform.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04153704 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-79280f06cb7a4cc8b10ff25d5b19e412 |
| 출처 메모 | uspto-grants-1979_05 |