Potassio isocyanate → 3-Phenyl-2,3-dihydro-1H-indole-1-carboxamide

HRID 262301

반응식

HRID 262301 반응식
Cl.[C:2]1([CH:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:17]=[C:18]=[O:19].[K+]>O.C(O)C>[C:18]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9]1)(=[O:19])[NH2:17]

참가 물질

5

반응물 2

HCID 11051572Potassio isocyanateHCID 213204633-Phenyl-2,3-dihydro-1H-indole--hydrogen chloride (1/1)

생성물 1

HCID 538455683-Phenyl-2,3-dihydro-1H-indole-1-carboxamide

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture comprising 2.3 g of 3-phenyl indoline hydrochloride in 23 ml of water and 0.81 g of potassium isocyanate in 23 ml of ethanol was stirred for 15 minutes at room temperature. The precipitate which resulted was filtered off, washed with water and recrystallized from dilute ethanol. The yield of N-carbamoyl-3-phenylindoline was 0.9 g and the product had a melting point of 144°-145° C.

후처리

  1. customThe precipitate which resulted
  2. filtrationwas filtered off
  3. washwashed with water
  4. customrecrystallized from dilute ethanol

출처 및 근거

ORD 기록
ord-a26935f1678c4ebe8890882cefa5be19
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04153789

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