Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluoroiodobenzene → 4-Acetyl-4'-fluoro-2-nitrobiphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluoroiodobenzene | HCID 9605 | — |
| 반응물 | 1-(4-Bromo-3-nitrophenyl)ethan-1-one | HCID 87737 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Acetyl-4'-fluoro-2-nitrobiphenyl | HCID 21320555 | — |
반응 단계
4-fluoroiodobenzene and 4-bromo-3-nitroacetophenone were reacted under Ullmann conditions to give 4-acetyl-4'-fluoro-2-nitrobiphenyl, m.p. 88°-90° C. (from methanol). This compound was reduced with stannous chloride in concentrated hydrochloric acid to give 4-acetyl-2-amino-4'-fluorobiphenyl, m.p. 88°-91° C. (from methanol). The amino group in this compound was converted to methoxy in the following way:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04153807 |
| 출처 데이터셋 | uspto-grants-1979_05 |
| ORD ID | ord-04f76ec2a7f6441cb011856833208acf |
| 출처 메모 | uspto-grants-1979_05 |