Methyl chloroacetate → 2-Chloro-N-(2,3-dihydroxypropyl)acetamide

HRID 262352노트

반응식

HRID 262352 반응식
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][OH:5].[Cl:7][CH2:8][C:9](OC)=[O:10]>CO>[OH:6][CH:3]([CH2:4][OH:5])[CH2:2][NH:1][C:9](=[O:10])[CH2:8][Cl:7]

참가 물질

4

반응물 2

HCID 7295Methyl chloroacetateHCID 735613-Amino-1,2-propanediol

생성물 1

HCID 132331202-Chloro-N-(2,3-dihydroxypropyl)acetamide수율 95%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A solution of 25 grams (g.) (0.27 mole) of 3-amino-1,2-propanediol in 50 milliliter (ml.) methyl alcohol is added slowly to a solution of methyl chloroacetate, 33.0 g. (0.30 mole) in 50 ml. methyl alcohol at 5°-10° C. The solution is stirred for five hours at 5°-10° C. and is then allowed to stand in the cold for four days. The solution is then evaporated in vacuum to leave 43 g. of the desired product, a viscous oil, nD30 1.5148. (95% yield).

후처리

  1. customat 5°-10° C
  2. customcold for four days
  3. customThe solution is then evaporated in vacuum
  4. customto leave 43 g

출처 및 근거

ORD 기록
ord-0381fb6ba5804630bbae354253dcf336
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154595

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