Ethanol → Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate

HRID 262392노트

반응식

HRID 262392 반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH:7]([C:9]([OH:11])=[O:10])[O:8][C:4]=2[C:3]=1[Cl:14].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[CH2:20]([O:10][C:9]([CH:7]1[CH2:6][C:5]2[CH:12]=[CH:13][C:2]([Cl:1])=[C:3]([Cl:14])[C:4]=2[O:8]1)=[O:11])[CH3:21]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 98160656,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic Acid

생성물 1

HCID 12747889Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate

실험 절차

A solution of 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid (70 g.) conc. sulfuric acid (2 ml.) and ethanol (250 ml.) is refluxed for 2 hours. The ethanol is distilled at reduced pressure and the residue is suspended in saturated sodium bicarbonate and extracted with ether. The ether solution is washed with brine, dried over magnesium sulfate and the ether distilled at reduced pressure. The 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester is used without further purification in the following synthesis.

후처리

  1. distillationThe ethanol is distilled at reduced pressure
  2. extractionextracted with ether
  3. washThe ether solution is washed with brine
  4. dry with materialdried over magnesium sulfate
  5. distillationthe ether distilled at reduced pressure
  6. customThe 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester is used without further purification in the following synthesis

출처 및 근거

ORD 기록
ord-d75126ef37764e2a97651c28c879cc8e
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154742

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