참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 2-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate | HCID 23698133 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Hydroxybenzyl cyanide | HCID 26548 | — |
반응 단계
A stirred suspension of sodium p-hydroxymandelate monohydrate (50 g. of 77% w/w material, the impurity being sodium chloride) and sodium cyanide (12.5 g.) in N,N-dimethylformamide (67.5 ml.) is heated at 135° C. for 2 hours and then cooled. Water (200 ml.) and formic acid (20 ml.) are added and the mixture is extracted twice with methyl isobutyl ketone (200 ml. and 100 ml.). The combined extracts are washed twice with water (50 ml. each time) and are then concentrated by evaporation. There is thus obtained a solution of p-hydroxybenzyl cyanide in methyl isobutyl ketone which is suitable for conversion to p-hydroxyphenylacetamide without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04154757 |
|---|
| 출처 데이터셋 | uspto-grants-1979_05 |
|---|
| ORD ID | ord-1413b00779fe4c989f620225bd258016 |
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| 출처 메모 | uspto-grants-1979_05 |
|---|
