2-[(Thiazol-2-yl)methylthio]ethylamine → 2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone

HRID 262495노트

반응식

HRID 262495 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=2)=[CH:3][CH:2]=1.[S:17]1[CH:21]=[CH:20][N:19]=[C:18]1[CH2:22][S:23][CH2:24][CH2:25][NH2:26]>>[S:17]1[CH:21]=[CH:20][N:19]=[C:18]1[CH2:22][S:23][CH2:24][CH2:25][NH:26][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[CH:13][N:12]=1

참가 물질

3

반응물 2

HCID 129234032-[(Thiazol-2-yl)methylthio]ethylamineHCID 143385852-(Methylthio)-5-(pyridin-4-ylmethyl)pyrimidin-4(1H)-one

생성물 1

HCID 143385912-[2-(2-Thiazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone

실험 절차

An intimate mixture of 5-(4-pyridylmethyl)-2-methylthio-4-pyrimidone (1.55 g) and 2-(2-thiazolylmethylthio)ethylamine (1.16 g) was heated at 135°-140° with frequent stirring. After cooling, the reaction mixture was triturated under water to give 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone. This product was acidified with dilute ethanolic hydrogen chloride, evaporated to dryness and the residue recrystallised from methanol to give the title compound m.p. 190°-195°.

후처리

  1. temperaturewas heated at 135°-140° with frequent stirring
  2. temperatureAfter cooling
  3. customthe reaction mixture was triturated under water

출처 및 근거

ORD 기록
ord-8c030c4cebd7407d95e9858b6a4f7bfe
출처 데이터셋
uspto-grants-1979_05
특허 번호
US04154834

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